Throughout the bioprocess industry, the use of disposable systems such as bioreactors is playing an increasingly significant role. Manufacturers are recognizing the strategic benefits of single use systems in both reducing production costs and increasing overall manufacturing throughput. The growing demand for larger scale, disposable bioreactor systems to satisfy the manufacturing demands puts an emphasis on suppliers such as Merck Millipore to demonstrate robust and reproducible scale-up within these systems. This presentation explores the design philosophy behind the Mobius� CellReady bioreactors and provides an overview of the novel SensorReady external sensing technology. Examples of experimental data of process scale-up from the 3L bench top units to the 200L pilot, disposable bioreactor units are presented and discussed with experimental data demonstrating the robustness of the novel SensorReady technology from the initial design concept and testing performed by Merck Millipore R&D (Bedford, USA) through to the real world, comparative process data obtained from the 50 and 200L CellReady units in Merck Biodevelopment (Martillac, France).

Robust scalability of CellReady bioreactor platforms

245th National Meeting (2013)

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