The Thomsen Friedenreich antigen (TF-ag), a tumor associated carbohydrate antigen (TACA), is a simple mucin type disaccharide that is rarely presented on normal cells but commonly displayed on the cell surface of human carcinomas. Serum antibodies to TF-ag are protective in cancer patients, and hence the structure has been the target of many antitumor vaccine and immunotherapeutic strategies. In addition, several reports have shown that TF-ag is directly involved in the metastatic spread of various tumors by engaging the serum galactoside-binding lectin galectin-3 (Gal-3), causing an exposure of adhesion molecules and endothelial anchoring leading to extravasation. We here in describe the synthesis and characterization of TF-antigen functionalized gold nanoparticles as potential inhibitors of the TF-ag/Gal-3 interaction for possible development of novel antimetastatic agents. The preparation, biological evaluation and the effect of ligand density on the potency of these nanoparticles will be discussed.

Synthesis of Thomsen Friedenreich antigen-loaded gold nanoparticles as potential anticancer agents

245th National Meeting (2013)

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