Through a detailed analysis of the physical/structural properties of Pd-NHC complexes, which includes NMR spectroscopy, rate studies, and calculation, a high-performing catalyst has been developed that very effectively cross-couples amines to aryl and heteroaryl chlorides under very mild reaction conditions. In this presentation, the evolution of the two most reactive catalysts for this transformation, Pd-PEPPSI-IPent and Pd-PEPPSI-IPentCl, will be discussed. Applications to the preparation of trialrylamines will also be elaborated.

Recent advances in metal-catalyzed amination using Pd-NHC complexes

245th National Meeting (2013)

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