The combination of multi-step heterogeneous transition metal catalysis and aminocatalysis for asymmetric cascade reactions is disclosed. It was demonstrated by the development of an aerobic-oxidation/Michael-addition/carbocyclization cascade transformation that delivered functionalized cyclopentenes, dihydrofurans and spirocyclopentene oxindoles in high yields with excellent stereoselectivity starting from allylic alcohols using bench-stable Pd and chiral amine co-catalysts.

Combined multistep heterogeneous transition metal catalysis and aminocatalysis for asymmetric cascade reactions

245th National Meeting (2013)

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