A modular synthesis of the potent molluscicide, cyanolide A, has been developed to provide facile access to a series of cyanolide A analogues. The key reactions involved are reductive alkylation, Prins cyclization, and Shiina's lactonization. The synthesis of strategic derivatives has been initiated in order to determine the structural features of cyanolide A required for molluscicidal activity.

Synthetic studies toward cyanolide A and analogs

245th National Meeting (2013)

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