The installation of vicinal quaternary centers remains a challenge in organic synthesis. As an extension of our work in this field, we aim to synthesize the novel lycopodium alkaloid palhinine A. Our approach utilizes a Morita�Baylis�Hillman reaction and an intramolecular Diels�Alder reaction sequence to access the isotwistane core containing the vicinal quaternary centers. Synthetic studies of this strategy will be discussed.

Progress toward the total synthesis of palhinine A

245th National Meeting (2013)

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