Peptide mimics that display amino acid side-chains on semi-rigid scaffolds without polyamide backbone components can exist in conformations that overlay with helical secondary structures, and are therefore �minimalist helical mimics�. A new protocol based on a conformational ensembles to calibrate goodness of fit of minimalist peptidomimetics on ideal secondary structures was proposed and used to compare some of the most widely cited minimalist helical mimics. Some �helical� minimalist mimics have alternative non-helical conformations that more closely resemble non-helical secondary structures.

How helical are minimalist helical mimics?

245th National Meeting (2013)

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