The search for novel chemotherapeutic approaches for cancer treatment is an active research field. Recently, a new appealing target, the reverse transcriptase enzyme telomerase, has attracted a lot of attention because this enzyme is over-expressed in 80-85% of cancer cell types and inactive in normal somatic cells. It has been demonstrated that inhibition of telomerase induces cell senescence and death and, for this reason, it has become a very important target for cancer therapeutics. In this work we present the synthesis and telomerase inhibition studies of novel coumarin ligands that could represent a potential novel type of anticancer drugs.

Synthesis of novel coumarin ligands as potential telomerase inhibitors

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.