Carcinogenesis is the transformation of a normal cell into a cancerous cell.  Cancer chemoprevention is the use of natural and synthetic compounds to stop or reverse carcinogenesis. These compounds have been labeled chemopreventives. Mechanistically, chemopreventives takes advantage of the human body's natural defenses to stop or reverse carcinogenesis. The goal of this project is to synthesize compounds to be used as drug candidates that can be used as chemopreventives. We have made chalcones and chalcone derivatives as possible chemopreventives. Chalcones have demonstrated antibacterial, antifungal, antitumor, and anti-inflammatory properties. We have synthesized and characterized a series of methoxy and boronic acid chalcones via adol condensation. Our synthetic methodology included the conversion of hydroxybenzaldehydes that were converted into alkoxybenzaldehydes via Williamson Ether Synthesis. The synthesized chalcones were characterized using GC-MS, IR, 1 H, 13 C, and 2D NMR spectroscopy and were shown to exhibit yields ranging from 23% to 91%.

Synthesis and characterization of boronic chalcones as potential cancer chemoprevention drug candidates

245th National Meeting (2013)

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