Layered double hydroxides (LDH) are versatile, biodegradable and biocompatible inorganic materials whose anion-exchange ability results specially attractive for the preparation of of hybrid and biohybrid materials for diverse uses including biomedical applications with special emphasis in the biomedical field. In this way, anionic drugs, pesticides or DNA biomolecules have been satisfactorily assembled to LDH and tested as controlled delivery systems (DDS) in which their sensitivity to pH is used to provoke the release of the intercalated species. DDS in which the LDH-drug hybrid is coated with a protective polymeric matrix show a more controlled drug release. The formation of bionanocomposites by assembling of LDH to biopolymers and other biomolecules, such as phospholipids, profits from the versatility of methodologies for the LDHs synthesis in comparison to smectites and other clays. In this communication we will try to illustrate how LDH-based bionanocomposites can be used as DDS introducing examples of various approaches.

Layered double hydroxides-based bionanocomposites for drug delivery applications

245th National Meeting (2013)

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