We report the synthesis of a linear polymer that reversibly undergoes intramolecular cross-linking to fold from an expanded coil into a globule utilizing disulfide bridges. We showcase this route to synthesizing robust, reversible single-chain polymeric nanoparticles that respond to reductive and oxidative stimuli. Characterization via size exclusion chromatography with in-line multi-angle laser light scattering and viscometry confirms changes in absolute molecular weight and conformation.

Single-chain polymer nanoparticles via reversible disulfide bridges

245th National Meeting (2013)

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