Systematic investigation on the rheology modulation of octadecyl (C18) modified poly(acrylic acid) (C18-PAA) by inclusive association between beta-cyclodextrin (CD) and C18 and the enzymatic degradation of CD was reported.The hydrophobic association among C18 grafts in C18-PAA showed high viscosity over the critical concentration in waster. Upon addition of CD, the viscosity reduced dramatically because of the masking of C18 groups by CD with the inclusion association. After introduction of the enzyme a-amylase, the viscosity increased significantly due to the recovery of hydrophobic association by damaging a-1, 4 glycosidic bond of cyclodextrin.In this way, the rheological properties of the hydrophobic associated polymeric networks can be tuned. This work opens a new way to prepare biodegradable polymeric networks for controlled drug delivery.

Rheology modulation of hydrophobic associated polymeric networks by cyclodextrin inclusion and enzymatic degradation

245th National Meeting (2013)

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