Polyether polyols like poly(glycerol) (PG) can be used as very potent and multifunctional alternatives to conventional monofunctional PEG. By transferring this analogy to macromonomers, we developed two different protocols for the synthesis of PG-based macromonomers, ranging from direct end-capping of oligo(glycerol) synthesized by anionic ring-opening polymerization to amphiphilic macromonomers prepared by click chemistry. The combination of the biocompatible polyether polyol structure with polymerizable methacrylate endgroups gives access to diverse macromolecular architectures or biohybrids via controlled radical polymerization techniques, e.g., ATRP.

Combining anionic polymerization and click-chemistry: Poly(glycerol)-based macromonomers for bioconjugation

245th National Meeting (2013)

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