Two triblock polymers were prepared by condensing two equivalents of the diblock copolymer, CH3O-(CH2CH2O)43-(COCH2CH2CH2CH2CH2O)9-H, with one equivalent of either hexamethylene diisocyanate or isophorone diisocyanate. Another triblock polymer was prepared by condensing two equivalents of poly(ethylene glycol) monomethylether, Mn~2,000, two equivalents of isophorone diisocyante and one equivalent of polycaprolactone diol Mn~14,000. The CMC increased with increasing temperature, see figure below, and was in the range of 5 to 10 mg polymer per liter at 25 �C. Microcal DSC showed a melting endotherm indicating the polycaprolactone core was semi-crystalline. Dibucaine was loaded into the polymer micelles and the isothermal release rate was determined at 37 �C and at 57 �C.

On the thermal behavior, drug loading capacity, and thermally triggered release from polymer micelles made from poly(ethylene glycol-b-caprolactone-b-ethylene glycol) triblock polymers

245th National Meeting (2013)

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