The objective of this study is to synthesize new antibacterial dental monomers based on quaternary ammonium salts and test them for cytotoxicity and antibacterial activity against cariogenic bacteria and other bacteria. New antibacterial dental monomers have been synthesized and characterized by NMR, IR and MS. They have been tested for cytotoxicity with human gingival fibroblast cells and all were found to be biocompatible at concentrations of 10-5 M and below. Their efficacy in inhibition of planktonic growth of four bacteria (Streptococcus mutans, Lactobacillus casei, Staphylococcus aureus and Pseudomonas aeruginosa) was examined using BioscreenTM. The results indicate that monomers containing a long (i.e. hexadecyl) alkyl chain are superior to their shorter chain counterparts. The monomers containing alkyl dimethylbenzyl ammonium salts were better than the similar structures containing 1,4-diazabicyclo[2.2.2]octane (DABCO) in some cases. The long-chain antibacterial dimethacrylate monomers showed activities slightly less than or comparable to chlorhexidine in all cases. 

Synthesis and characterization of new antibacterial dental monomers

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.