The protein nuclear factor-kappa B (NF-?B) is a transcription factor which is critical in cellular response to inflammation, apoptosis, and immune response.  Inhibitor of kappa B (I?B) molecules inactivate NF-?B, keeping the protein within the cytoplasm.  Phosphorylation of I?B degrades the inhibitor, allowing for NF-?B passage into the nucleus where it regulates the expression of numerous genes related to immune and inflammatory response.  While NF-?B is crucial for immune response, its untimely activation and the overexpression of certain inflammatory proteins can result in various diseases such as cancer and many neurological disorders.  Peptides mimicking I?B will be designed to study specific interactions that are key to binding of NF-?B by I?B.  The peptides with highest binding affinities for the protein will be screened as broad based inhibitors for the NF-?B signaling pathway.  Fluorescence binding studies and CD structure studies will be completed to characterize all designed peptides.

Peptides designed for biomimetic studies of NF-κB inhibition

245th National Meeting (2013)

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