Recent studies have shown the medicinal benefit of manganese-porphyrin complexes as radiation mitigators in mice. These studies have shown that clearance of H2O2 within the mitochondria has led to the inhibition of apoptosis, resulting in increased radiomitigative potential from irradiation with ?-rays. Although the manganese-porphyrin complex was able to clear H2O2 form the mitochondria, it failed to protect against superoxide (O2-�) free radicals. To enhance the pharmacological effectiveness and radiomitigative potential, we tested the ability of porphyrin-Mn2+ complex to be derivatized, using HPLC, with 4-carboxy-2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), to clear O2-� within the mitochondria. We report that the substitution of the triphenylphosphonium functional group of the Mn2+-porphyrin complex with TEMPO yielded a pharmacologically inactive complex.

Manganese-porphyrin complex used as a potential radiation mitigator

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.