Bioinorganic chemistry is a rapidly growing field with vast pharmaceutical applications.  Notable advances have been made in the treatment of a number of complex diseases, including cancer and HIV.  The neocarzinostatin metabolite has been well characterized in its binding affinity for a specific hairpin loop structure found on the trans-activating response element (TAR) located on HIV RNA, giving the metabolite potential as an HIV therapeutic.  Synthesis of the metabolite through traditional organic chemistry has shown to be difficult, so a transition metal analog has been designed to simplify the synthesis and facilitate structure-activity studies.  Progress toward the synthesis of this metabolite core is discussed and the applicability of this methodology to additional RNA sequences and natural products is outlined.

Progress toward synthesis of a transition metal coordination complex analog of the neocarzinostatin metabolite core

245th National Meeting (2013)

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