Angelmarin, a coumarin-based natural product isolated from the root of the Japanese medical plant Angelica pubescens, has displayed promising activity against pancreatic adenocarcinoma cell line PANC-1. Given this compound's potential as a pancreatic cancer therapy, structure-activity relationship (SAR) studies have been initiated to discover even more effective compounds and to further investigate the compound's molecular target. A novel geranylgeranylated ether coumarin derivative has been identified as a promising lead structure for further development of novel compounds as pancreatic cancer chemotherapeutics. Cytotoxicity data for a novel lead series against PANC-1 cells under nutrient rich and nutrient deprived conditions will be presented.

Biological evaluation of a novel series of isoprenylated coumarins as promising pancreatic cancer therapies

245th National Meeting (2013)

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