The Hypericum plant genus has been a consistent source of biologically active natural products. Previous phytochemical studies of hexane and acetone extracts of the leaves of Hypericum ellipticum have afforded a new acylphloroglucinol derivative (elliptophenone A), two new xanthones (elliptoxanthones A and B) and a new benzophenone glucoside (3'-O-beta-D-3'',4'',6''-triacetylglucopyranosyl-2,4,5',6-tetra-hydroxy benzophenone). Some of these compounds exhibited moderate cytotoxicity towards human colon tumor cell lines. In the current study, the methanol extract of Hypericum ellipticum has yielded 3'-O-beta-D-3'',4'',6''-triacetylglucopyranosyl-2,4,5',6-tetra-hydroxy benzophenone, together with other flavonoids and flavonoid glycosides. The compounds were purified using Sephadex LH 20, silica gel and C18 RP column chromatography, together with RP HPLC. Structures were determined on the basis of 2D NMR, IR and MS analyses.

Chemical constituents of a methanol extract of Hypericum ellipticum

245th National Meeting (2013)

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