Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) plays a vital role in both cell proliferation and intercellular communication. Over-activation of LMW-PTP has been linked to the transformation of cells in the liver, kidney, and breast. Past research has shown the National Cancer Institute's diversity set I and II both contained inhibitors targeted against LMW-PTP. Our research is focused on the identification of novel inhibitors of LMW-PTP based on the National Cancer Institute's diversity set III. Inhibitors were first identified via virtual screening using Maestro (Schrodinger LLC) before being tested through an enzymatic assay.  We also attempted synthesizing inhibitors based on the structure of a known inhibitor, pyridoxial 5' phosphate (PLP).  Results of these efforts will be presented.

Identification of new inhibitors targeted against low molecular weight protein tyrosine phosphatase

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.