Nicotinic receptors control the release of numerous neurotransmitters, including dopamine, acetylcholine, and norepinephrine, and holds promise for treating diseases such as attention deficit hyperactivity disorder (ADHD), Parkinson's and Alzheimer's diseases, and schizophrenia. Our goal is to find analogs that have the potential to bind to the nicotinic receptor, causing the release of these neurotransmitters; and not cause increased heart rate, blood pressure, and nausea that are a result of nicotine usage. The synthesis, purification, characterization, and time dependent toxicity of nicotine analogs will be presented.

Synthesis and time dependent toxicity of nicotine analogs

245th National Meeting (2013)

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