Several new acetylpyrazine thiosemicarbazone ligands have been synthesized in our laboratory and characterized by 1H NMR spectrometry. These new compounds have been shown to ligate transition metals such as Pd2+ and Cu2+ through an N-N-S tridentate system. These biologically active compounds were tested for antimicrobial activity by determining the minimum inhibitory concentrations against four bacteria (Bacillus subtilis, Saphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), two yeast (Canida albicans and Sacchromyces cervisiae), and one mold (Aspergillus niger). Tests show that the Cu2+ and Pd2+ complexes of these ligands exhibit different activities than the individual ligands.

Synthesis and antimicrobial studies of acetylpyrazine-thiosemicarbazone (APZ-TSC) ligands and their complexes of Pd<sup>2+</sup> and Cu<sup>2+</sup>

245th National Meeting (2013)

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Synthesis and antimicrobial studies of acetylpyrazine-thiosemicarbazone (APZ-TSC) ligands and their complexes of Pd2+ and Cu2+

Synthesis and antimicrobial studies of acetylpyrazine-thiosemicarbazone (APZ-TSC) ligands and their complexes of Pd²⁺ and Cu²⁺