Burkholderia cenocepacia is a bacterial strain responsible for causing infections in the lungs of cystic fibrosis patients. This Gram-negative strain is multi-drug resistant with a highly impermeable outer membrane. The impermeability of Gram-negative bacteria is due in part to a high concentration of lipopolysaccharide (LPS) molecules in the outer membrane. Based on sequence homology with similar genes in E. coli, the BCAL0894 gene is expected to play a part in the mechanism responsible for inserting LPS into the outer membrane of B. cenocepacia. Current studies are working towards a gene knockout of BCAL0894, which will determine if the protein is essential for B. cenocepacia viability.

Gene knockout of an outer membrane protein in Burkholderia cenocepacia

245th National Meeting (2013)

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