Pyruvaldehyde was reacted with seven different thiosemicarbazide compounds to give a series of seven pyruvaldehyde bis-thiosemicarbazone compounds. These complicated compounds were characterized by 1H NMR. The compounds produced are: pyruvaldehyde bis-thiosemicarbazone, pyruvaldehyde bis-methylthiosemicarbazone, pyruvaldehyde bis-ethylthiosemicarbazone, pyruvaldehyde bis-tertbutylthiosemicarbazone, pyruvaldehyde bis-benzilthiosemicarbazone,  pyruvaldehyde bis-phenylthiosemicarbazone, and pyruvaldehyde bis-dimethylthiosemicarbazone. These compounds were reacted with various metals to form metal complexes and then tested to prove or disprove biological benefits. The antimicrobial activity of these synthesized pyruvaldehyde thiosemicarbazones and the metal complexes of these compounds will be tested by determining the minimum inhibitory concentrations against four bacteria (Bacillus subtilis, Saphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), two yeast (Canida albicans and Sacchromyces cervisiae), and two molds (Aspergillus niger).

Pyruvaldehyde bis-thiosemicarbazone ligands and metal complexes

245th National Meeting (2013)

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