The naphthoquinone adduct 12,13dihydro-N-methyl-6,11,13-trioxo-5H-benzo[4,5]cyclohepta[1,2-b]naphthalen-5,12-imine (hereafter called TU100) has been identified as a cytotoxic agent against various cancer cell lines. It can function as a topoisomerase inhibitor, but it is unclear whether this activity is responsible for its effects on cell viability. TU100 can also inhibit luciferase, a class of oxidative enzyme involved in bioluminescence. In this regard it is similar to resveratrol, a well known component of red wine associated with longevity and anti-cancer effects.  To identify other potential biological targets of TU100, tissue culture cells were treated with TU100 and effects on other oxygenases like monoamine oxygenase and resveratrol targets such as Sirtuin 1 were analyzed.

Identifying biological targets of the novel naphthoquinone adduct 12,13dihydro-N-methyl-6,11,13-trioxo-5H-benzo[4,5]cyclohepta[1,2-b]naphthalen-5,12-imine

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.