The frizzy (fr) mutation has previously been assigned to the Prss8 gene on mouse Chromosome 7. The retarded hair growth (rhg) and frizzy-like (frzl) mutations also generate hair defects and map to the same region as fr, but whether they are alleles of Prss8 or mutations in distinct genes is not known.To discover the genetic relationship among these mutations, I have crossed all pair-wise combinations of these variant mice and have shown that all three mutations complement, and therefore must lie in distinct genes. To identify alternative gene candidates by a positional approach, I have mapped rhg between markers that flank fewer than 25 genes. One of the genes in this interval, Fgfr2, is known to be required for normal hair development. But, since mice carrying both Fgfr2? and rhg or Fgfr2? and frzl are normal, I conclude that neither of these mutations is a defect in Fgfr2.

Three hair mutations, frizzy (fr), frizzy-like (frzl), and retarded hair growth (rhg), disrupt distinct genes on mouse chromosome 7

245th National Meeting (2013)

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