Perfluorinated compounds (PFC) are organic compounds where C-H bonds have been replaced with C-F bonds. A new PFC named undecafluoro-2-methyl-3-oxahexanoic acid (U2M3-OHxA) is a potentially less toxic replacement for current PFCs. Immunotoxicity was tested using C57BL/6 mice that were exposed to 0, 1, 10, and 100 mg/kg of U2M3-OHxA by gavage for 28 days. Body and organ weights were recorded and spleens were used for immunophenotyping. Mice were immunized with sheep red blood cells on day 24 and ELISAs were used to measure the IgM antibody responses.  Results showed a loss in body weight for females in the 100 mg/kg group, increased liver weight for 10 and 100 mg/kg doses, increased thymus weight for the 100 mg/kg males, decreased splenic weight for 100 mg/kg females, a decrease in the CD45 (B cell) splenic lymphocytes for males in the 1 and 100 mg/kg dose groups, and no changes in IgM responses.

Immunotoxic effects of undecafluoro-2-methyl-3-oxahexanoic acid in mouse models

245th National Meeting (2013)

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