The simplicity of the Flock House virus (FHV) capsid and genome, along with the wealth of available structural information, make FHV an excellent model system for studying viral infection. Lachesin, a receptor protein in Drosophila, has been proposed as the receptor protein required for FHV to infect Drosophila. Still, no conclusive evidence demonstrating FHV binging to lachesin has been presented. In my research, I will use Gateway cloning to demonstrate that a) lachesin does bind FHV and b) lachesin is necessary for FHV infection. Once the receptor protein for FHV is determined, the interactions between FHV and the receptor can be characterized. This will lead to a better understanding of how FHV and other non-enveloped viruses, that cause serious human disease, infect host cells.

Determination of lachesin as a cell surface receptor protein for flock house virus using gateway cloning in Saccharomyce cerevisiae

245th National Meeting (2013)

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