Morinda Citrifolia also known as Noni has a long history of use as a medicinal plant because of its antioxidant, anti-inflamatory and hepatoprotective properties. To determine Noni effect in Cytochrome P450 isoenzymes, aqueous and organic extractions from the seeds and the skin were prepared. Extracts were analyzed by HPLC. CHO cells were treated for 48 hours. Microsomes were prepared. Protein and erythromicyn-N-demethylase assays were perfomed. Enzyme activity was determined to establish the effect of Noni in the system. Results showed a low concentration of protein in the experimental groups: 0.0306�g/ml (pulp), 0.0306�g/ml (aquous skin extract) and 0.0305 �g/ml (organic skin extract). Results from the erythromicyn-N- demethylase assay showed no activity. Results suggest a decrease in activity.

Effect of Morinda citrifolia on the erythromicyn-N-demethylase and cytochrome P450 activity

245th National Meeting (2013)

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