Poly(ethylene glycol)-b-polycaprolacton(PEG-b-PCL) conjugated porphyrin copolymer could be successfully prepared by the combination of ring-opening polymerization(ROP) and click reaction. Both PEG-c-porphyrin and PEG-PCL-porphyrin can self-assemble into micelles in aqueous environment. The core-shell micelles structure was confirmed by transmission electron microscopy(TEM) and dynamic laser scattering(DLS). The micelles exhibited sizes around 100 nm and have a narrow size distribution. These functional amphiphilic copolymer micelles have potential use as therapeutic or drug delivery systems.

Synthesis and self-assembly behavior of poly(ethylene glycol)-b-polycaprolactone conjugated porphyrin copolymer

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.