The current study is aimed at evaluating the ability of select polymers to inhibit two pancreatic cancer cell lines. The cell lines tested are AsPC-1 which is an adenocarcinoma pancreatic cell line and PANC-1 which is an epithelioid carcinoma pancreatic cell line.  Both are human cell lines and are widely employed in testing for inhibition of pancreatic cancer. The second aspect concerns a comparison of the two most widely cell lines employed in the evaluation of the effectiveness of compounds to arrest the growth of tumor cell lines.  These two cell lines are the NIH/3T3 and WI-38 cell lines. Since the NIH/3T3 are easier to handle they are often favored over the WI-38 human cells.  In comparison to some of the organotin polymers tested, the compounds, monomers and polymers, tested in the current study exhibit low toxicity to the cell lines tested.  For the Group IVB metallocenes results are generally consistent with the polymers offering superior GI50 (lower) and CI50 (higher) values in comparison to cisplatin.  Some of the polymers offer high CI50 values consistent with a large concentration window favoring inhibition of the pancreatic cancer cell lines and merit further testing. In most cases, the GI50 and CI50 values using WI-38 and NIH/3T3 cells are similar.  Further testing is needed to be more confident in this.  If it is true, then use of NIH/3T3 standard cells would be favored because of their ease in handling and greater hardiness.

Comparison of employing WI-38 and NIT/3T3 cells for evaluation of chemotherapeutic index and growth inhibition values for pancreatic cancer cell lines for group IVB metallocene and group VA metal-containing polymers derived from glycyrrhetinic acid, 3,5-pyridinedicarboxylic acid, and histamine

245th National Meeting (2013)

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