DNA-programmed polymeric nanoparticles are presented as stable nucleic acid delivery vehicles that facilitate communication with biological entities in a specific and predictable manner.  Based upon the three-dimensional architecture and spatial arrangement of nucleotides at the surface-solution interface, these materials exhibit unique interactions with biologically relevant constituents such as enzymes, proteins and cell membranes.  These interactions can be tuned by structure and sequence in order to provide a promising class of information-rich materials.

DNA-programmed polymeric micelles

245th National Meeting (2013)

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