With the presence of PPCPs in water now reported frequently and the synergistic effects of low doses largely unknown, the need for sensitive and rapid analytical measurement of these compounds is paramount. The traditional method to achieve low detection limits has been to use off-line concentration techniques like solid-phase extraction (SPE) or large volume injection (LVI). This method requires large sample volume, is time consuming and labor-intensive. Trace enrichment or on-line SPE eliminates all these difficulties while providing sample clean-up and reduces interferences which LVI cannot do. In this study, a single automated analytical method for the analysis of over 20 PPCPs (both in ESI- and ESI+) using on-line SPE coupled to a tandem mass spectrometer will be shown. Critical parameters like sample loading volume, extraction cartridge and elution solvents will also be discussed. The results will be compared to off-line SPE with time, labor and solvent usage considerations.

On-line SPE coupled to LC MS/MS for rapid, sensitive, and simultaneous analysis of multiple PPCPs in water

245th National Meeting (2013)

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