Chromatographic systems require care and maintenance to ensure high performance and reliable results.  Regular use of a system suitability standard can help benchmark system performance over time to ensure a well-operating system and quality data collection.  When the performance of the system suitability standard falls out of specification, the suitability standard can help identify and diagnose potential system problems.  In the event of a problem with the system, troubleshooting must be performed to identify the source of the problem.  Troubleshooting system issues can be a very time consuming process, reducing laboratory productivity.  In this application, a suitability standard comprising of a mixture of neutral compounds is tested over several days to demonstrate its applicability in monitoring and benchmarking system performance.  The standard was then used to identify and troubleshoot an array of system problems, demonstrating the dual applicability of the suitability standard.  By routinely using a suitability standard, system performance can be evaluated prior to any samples being analyzed, ensuring that data is collected only under optimal system conditions and resulting in reliable and reproducible data generation.

Ensuring data quality and facilitating rapid system troubleshooting using a suitability standard

245th National Meeting (2013)

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