Graphene and its derivatives have attracted increasing attention due to their particular structures and unique properties. In request for demand on clinic diagnosis of some chronic diseases e.g. diabetic retinopathy, the development of novel biosensors based on graphene has attracted for intensive interests. Functionalized graphene with huge surface area can be used to efficiently immobilize enzymes, coenzymes, antibodies and DNA. The sensitivity and detection limit of biosensors can be enhanced readily. In the presented work, we will further demonstrate our recent study on ocular biocompatibility of graphene and its derivatives both in vitro and in vivo for the purpose of clinic diagnosis of ocular diseases. Well biocompatibility of graphene based biosensors can be achieved with incorporation of nitrogen-doping in the graphene matrix and surface modification techniques. One step preparation of functionalized graphene using new techniques such as the solid state ball milling will also be discussed.

Functionalized graphene-based catalysts and their applications in biosensors

245th National Meeting (2013)

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