Carbon nanotube field effect transistors (CNT FETs) are promising nanoscale tools for the electrical detection of biomolecular analytes. However, typical CNT FET-based sensors are difficult to modify with biomolecular recognition elements in high yield and exhibit poor sensitivity in complex biological media. We will discuss a strategy for the fabrication of massively parallel, independently-addressable CNT FETs encapsulated within a microfluidic housing. This housing enables the reliable modification of hundreds of CNT FETs with biomolecular recognition elements, allows for rapid delivery of arbitrary analytes to the independent devices, and minimizes complications associated with biofouling. We have applied this platform for the fully electrical monitoring of protein/DNA interactions. Our findings hold broad implications for the development of integrated, fully electrical sensing platforms.

Microfluidic-encapsulated carbon nanotube field effect transistors for the detection and monitoring of protein/DNA interactions

245th National Meeting (2013)

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