Abstract:   We are developing catalytic methods that feature stereoselective hydroacylation. Hydroacylation, the formal addition of an aldehyde C�H bond across an unsaturated functional group, is an ideal approach to carbonyl functionalities commonly found in bioactive molecules. We aim to advance hydroacylation as a unified strategy for transforming aldehydes into chiral esters, ketones, and amides. In this context, my lecture will discuss our most recent progress in the design, scope, and mechanism for hydroacylation methods using both rhodium and ruthenium catalysis. Our long-term goal is to develop more green, versatile, and efficient strategies for constructing heterocycles, polyketides, and other biologically relevant motifs.

Catalytic hydroacylation: Transforming C-H bonds to chiral esters and ketones

245th National Meeting (2013)

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