The 3-His-Fe2+ active site, binding motif can be exploited by Fe2+-substituted carbonic anhydrase (CA).  The activity of several 3-His-Fe2+ enzymes has been modeled successfully in with Fe-CA.  This method is also being modified to model the 2-His-3-Carboxylate facial triad motif.

3-His-Fe<sup>2+</sup> enzyme motif modeled by carbonic anhydrase

245th National Meeting (2013)

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3-His-Fe2+ enzyme motif modeled by carbonic anhydrase

3-His-Fe²⁺ enzyme motif modeled by carbonic anhydrase