Current commercial immunoassays detect trace levels of drugs in human matrices, but such analyses are not definitive. This research explores the use of nanogold fibers and commercial immunoassay plates as platforms for rapid sample clean-up coupled to Dart Analysis in Real Time (DART) for simultaneous detection. In preliminary experiments, alprazolam and diazepam were successfully extracted from plasma with an anti-benzodiazepine functionalized nanogold fiber then rapidly analyzed. Both compounds were definitively identified using DART with tandem mass spectrometry.

Rapid, definitive analyses of drugs in complex matrices using nanogold extraction coupled with DART-tandem spectrometry

245th National Meeting (2013)

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