As part of our efforts to minimize the use of toxic chemicals in organic chemistry instructional laboratories, a newly developed Knoevenagel�Doebner reaction in a multistep sequence to 2'-bromostyrene was developed and applied over a period of four semesters. The conventional base used during this reaction used to be pyridine, which is a highly toxic compound. We have been able to replace pyridine with a nucleophilic catalyst, DMAP, as well as discover and apply a microwave-mediated route. Herein, we will present the results and evaluations of this green reaction in second-year organic chemistry laboratory carried out during the past year.

Results and evaluation of a green approach to Knoevenagel–Doebner condensation reaction in a second-year organic chemistry laboratory class

245th National Meeting (2013)

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