Artemone is an antifungal natural product from the Indian sage Artemisia pallens. We have developed a direct, four-step synthetic route from (-)-linalool that features a stereoselective cyclization with an organocatalyst. This synthesis uses no protecting groups, minimizes redox manipulations, and seeks to maximize atom economy.

Four-step, stereoselective synthesis of artemone

245th National Meeting (2013)

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