The prevalence of obesity is increasing at an alarming rate, but, unfortunately, only a few medications are currently on the market. Attempts are been made to synthesize the molecules for anti-obesity effect. Thermogenesis is one of the major strategies worked for synthesis and evaluation of anti-obesity molecules. �-3 receptor agonists are studied in the past for their thermogenic and lipolytic activity.  Phenyl ethanolamine derivatives are very well studied for their anti-obesity property via activation of �-3 adrenergic receptor. In the present study, new phenyl propanolamine derivatives were synthesized by the Mannich reaction and successively by reduction. The synthesized molecules were screened for their lipolysis activity at 25�M and 50�M concentrations in the mature adipocytes nor epinephrine was used as positive standard. Cytotoxicity study of the compounds on the mature adipocytes was carried out using MTT assay. Results indicate that all the synthesized molecules were active for lipolysis on adipocytes.

Evaluation of lipolytic effect of pehnyl propanolamine derivatives in adipocytes

245th National Meeting (2013)

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