We are searching for food components preventing obesity by enhancing energy metabolism. We focus on compounds which activate thermosensitive TRP (transient receptor potential) ion channels. TRPA1 is cold sensor candidate. Here we investigated whether 1-acetoxychavicol acetate (ACA), a TRPA1 agonist and pungent principle of galangal, can suppress body fat accumulation in mice due to high energy diet. TRPA1 activity for racemic and S-form of ACA showed similar EC50 values and maximum responses in TRPA1-expressing cells. Next, C57BL/6J male mice were fed a high-fat, high-sucrose diet. Racemic ACA was added at 0.025 and 0.05% level. After 1 month of feeding, total energy intake were equal. Visceral fat weights decreased significantly. Blood glucose concetration was lower in both ACA groups. Expression of uncoupling protein 1 in interscapular brown adipose tissue increased in both ACA diets. These results indicate that ACA can suppress visceral fat accumulation.

1'-Acetoxychavicol acetate, a TRPA1 agonist, suppresses obesity due to high energy diet in mice

245th National Meeting (2013)

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