Metabonomics was more and more concerned in pharmacy studies, especially the traditional Chinese medicine which is also a holistic approach. Dragon's blood is a famous traditional Chinese medicine (TCM) since ancient time. The most important usage of the drug is in the treatment of blood stasis syndrome which is a common pathological syndrome in the elderly. Blood stasis syndrome is a significant pathological syndrome in TCM treatment theory. In the present work, an acute stasis rat model was established and confirmed by hemorheological examination. Then a metabolomic approach was applied to study the influence of dragon's blood on metabolic changes of the acute stasis rats. PLS-DA of the serum GC-MS fingerprints allowed discrimination of the controlled, stasis model, and stasis rats after administration of dragon' blood. And several significantly difference metabolites were found and identified including lactic acid, pyroglutamic acid, citric acid, glutamic acid, creatinine.etc.

Metabolomics study of antistasis effects of dragon's blood based on GC-MS

245th National Meeting (2013)

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