Epigallocatechin-3-gallate (EGCG), the major component of polyphenols in green tea, is a potent antioxidant that has many therapeutic applications including the treatment of cancers and inflammations. In this study, we examine the effect of EGCG and its hydrophobic derivative on cell biology of human epidermoid carcinoma A431, wildtype MCF-10A and mammary adenocarcinoma MCF-7 cells with the use of the quartz crystal microbalance with dissipation monitoring (QCM-D). The QCM-D detection is based on changes in mass and viscoelastic property of cells. We are particularly interested in the effect of these molecules on epidermal growth factor receptor-mediated cell signaling, the pathway that is essential to cell growth, survival, differentiation, and migration. Our study will shed light on why EGCG is an effective cancer-preventative agent.

Role of epigallochatechin-3-gallate as an anti-cancer agent in various cell lines

245th National Meeting (2013)

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