Ferrocene is a widely used compound due to its unique chemistry. One of its variants, ferrocene carboxylic acid, was used to synthesize halogen-substituted phenolic ester derivatives, which were cytotoxically examined in vitro with colon cancer and breast cancer cell lines (HT-29 and MCF-7) by means of the MTT biological assay. The IC50 of each compound was obtained. Results showed that ferrocene by itself has no significant cytotoxicity, but as moiety in organic molecules, it can be transported into the cell having anti proliferative effects. 4-chlorophenol ferrocenecarboxylate showed to be active against both types of cells; however, the 4-fluorophenol derivative is completely inactive. This shows promising data for the further development of effective therapeutic treatments. Further studies of cyclic voltammetry will be performed in order to determine the redox properties of the compounds.

In vitro antitumor activity study of new ferrocenecarboxylate derivatives on human colon and breast carcinoma cells (HT-29 and MCF-7)

245th National Meeting (2013)

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