Inulin, inulin-silica and modified inulin particle were prepared and used as drug delivery devices. Inulin-silica composite micro particles were synthesized in the presence of tetraethyl orthosilicate (TEOS) via a water-in-oil microemulsion polymerization technique. To generate pores, silica was removed from composite inulin particles. Furthermore, bare-inulin and porous-inulin particles were quaternized successfully by the treatment of 3-chloro-2-hydroxypropyl trimethyl ammonium chloride aqueous solution to generate the positive charge on the biopolymeric particles. SEM, optical microscopy, DLS, zeta potential measurement were used for the size, charge and morphology of the particles. Thermogravimetric analyzer (TGA) and FT-IR spectroscopy were utilized for thermal and functional structural characterization of p(inulin) particles. The antimicrobial activity of synthesized inulin particles was also investigated. Fluorescence sodium salt (FSS) and Rhodamine 6G (R6G) were used as model drugs for the release studies in phosphate buffer solution (PBS) at pH 7.4.

Preparation of biopolymeric particles from natural inulin

245th National Meeting (2013)

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