Tritrichomonas foetusis the causative agent of bovine trichomoniasis, a disease characterized by infertility, early embryonic death, rare abortions and uterine infections in cows and heifers. Even though trichomoniasis is a reportable disease, there is no treatment.  Based on our recent findings that Ara-F-Ado [9-(2-deoxy-2-fluoro-�,D-arabinofuranosyl)adenine]  is a potent inhibitor of T. vaginalis (IC5090 nM), we performed a structure-activity analysis in T. foetus on various adenosine and 7-deazaadenosine analogues. Ara-F-Ado was found to be an effective inhibitor of T. foetus with an estimated IC50 of 5-9 �M. From the 7-deazaadenosine compounds tested toyocamycin showed strongest inhibition of T. foetus (IC509.3 �M). Ara-F-Ado was also shown to be an inhibitor of the human protozoal parasites Entamoeba histolytica and Giardia with IC504.5 �M and 25 �M, respectively.

In vitro activity of nucleoside analogs on the veterinary protozoan parasite <i>Tritrichomonas foetus</i>

245th National Meeting (2013)

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In vitro activity of nucleoside analogs on the veterinary protozoan parasite Tritrichomonas foetus