N-heterocyclic carbene-supported gold complexes have contributed to a wide range of organic transformations including 1,6-enyne cycloisomerization, hydroarylation, [3,3] rearrangement, hydroamination, hydration and polymerization reactions. Despite the use of NHCs as prevalent supporting ligands, there has not been any detailed study that evaluates steric and electronic influences of ligands independently in gold catalyzed reactions. We methodically illustrate that changing the electronic and steric properties of the NHCs selectively modifies the product ratios formed in the 1,6-enyne cycloisomerization reactions.

Steric and electronic effects in homogeneous gold catalyzed 1,6-enyne cycloisomerization reactions

245th National Meeting (2013)

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